While working on our article, Training, Oxygen Systems, Hypoxic Tents. Success Factors for Climbing Everest and 8,000-Meter Peaks about climbing 8,000 meter peaks and the use of Normobaric Hypoxic Tents to pre-acclimatize, Dr. Monica Piris spearheaded the research effort by culling the recent editions of High Altitude Medicine and Biology and conducted searches of Pub Med and Plos One to find all publicly available articles about intermittent hypoxia, either training or sleeping.
When looking through these studies, it is worth noting that all of the studies were a) for periods of 7-14 days and b) only up to medium altitudes. Dr. Piris did include a very recent study on sleep disturbance in normobaric (normal air pressure) hypoxia vs hypobaric (low air pressure) hypoxia because it’s relevant to the tents and training. In that study they conclude that sleep disturbance is less in normobaric hypoxia and underline that normobaric hypoxia cannot be used to simulate hypobaric hypoxia because it is not the same to the body.
This list will expand as more research is published and we become aware of studies we weren’t initially aware of. If you have a public, peer-reviewed study that is relevant to this topic please email us at firstname.lastname@example.org and, upon review, we will add it to this resource-page.
Acute Normobaric Hypoxia Stimulates EPO Release. MacKenzie, 2008
Comparison of the effect of intermittent hypoxic training vs. the live high, train low strategy on aerobic capacity and sports performance in cyclists in normoxia. Czuba, 2018
Echocardiographic Assessment of Right Ventricle Dimensions and Function After Exposure to Extreme Altitude: Is an Expedition to 8000m Hazardous for Right Ventricular Function. Kurdziel, 2017
Surviving Without Oxygen: How Low Can the Human Brain Go? Bailey, 2017
Hypobaric Hypoxia Does Not Induce Different Responses from Normobaric Hypoxia + Rebuttal.pdf
High-Intensity Exercise in Hypoxia-Beneficial Aspects and Potential Drawbacks, Girard et al, 2018
Molecular Adaptations in Human Skeletal Muscle to Endurance Training Under Simulated Hypoxic Conditions, Vogt et al, 2001.
“Living High-Training low” Altitude Training Improves Sea Level Performance in Male and Female Elite Runners, Stray-Gundersen et al, 2001. (Note that this article addresses ‘real’ altitude not simulated altitude.)
Significant Molecular and Systemic Adaptations after Repeated Sprint Training in Hypoxia. Faiss et al, 2013.
The Effects of Intermit Tent Hypoxic Training on Aerobic Capacity and Endurance Performance in Cyclists. Czuba et al, 2011
Periodic High Altitude Exposure and Chronic Intermittent Hypoxia Are They the Same? Pun, M., 2017
Effects of Repeated-Sprint Training in Hypoxia on Sea-Level Performance: A Meta-Analysis, Brocherie et al, 2017
Simulated Altitude for Beneficial CV Outcomes in Non-athletes. A Literature Review. Lisamore and Hamlin, 2017.
Sleeping in Moderate Hypoxia at Home for Prevention of Acute Mountain Sickness (AMS): A Placebo-Controlled, Randomized Double-Blind Study. Dehnert et al, 2014
Effectiveness of Preacclimatization Strategies for High-Altitude Exposure. Fulco et al (2013)